Repligen MidiKros Hollow Fiber Filter mPES 750 kDa

Repligen MidiKros D06-E750-05-S Hollow Fiber Filter – Sterile mPES, 750 kDa, 370 cm2

The Repligen D06-E750-05-S is a precision-engineered MidiKros hollow fiber module designed for laboratory-scale Tangential Flow Filtration (TFF). Utilizing proprietary modified Polyethersulfone (mPES) membrane technology, this filter offers high flux rates and exceptional product recovery with minimal non-specific binding. This "S" designation indicates that the module is supplied Gamma Irradiated (Sterile), providing a ready-to-use, closed-system solution for aseptic bioprocessing. With a 750 kDa MWCO and an extended 370 cm2 surface area, it is optimized for the concentration and diafiltration of mid-volume biological samples, including viral vectors, large multi-meric proteins, and nanoparticles.

Technical Performance and Design

• Advanced mPES Membrane: The modified Polyethersulfone chemistry provides a hydrophilic, low-fouling surface that ensures high water permeability and excellent recovery of sensitive biomolecules (>95% typical recovery).

• 750 kDa Selective Barrier: Specifically tuned for large-molecule Ultrafiltration, providing high retention of viral particles while effectively clearing smaller host cell proteins and buffer components.

• Extended Surface Area: The 65 cm effective length provides 370 cm2 of filtration area, offering higher throughput and shorter processing times for batches up to 5 Liters compared to shorter laboratory modules.

• Gamma Irradiated (Sterile): Supplied sterile and ready for immediate integration into aseptic flow paths, reducing setup time and the risk of batch contamination.

Product Specifications

• Catalog Number: D06-E750-05-S

• Module Family: MidiKros

• MWCO: 750 kDa

• Surface Area: 370 cm2

• Effective Length: 65 cm

• Fiber ID: 0.5 mm

• Connections: Female Luer Lock (FLL) ports for secure, tool-free integration with standard lab-scale TFF tubing sets.

• Sterility: Gamma Irradiated (Sterile)

Key Benefits & Applications

• Viral Vector Processing: A premier choice for the concentration and buffer exchange of AAV and Lentiviral vectors in gene therapy research.

• Vaccine Development: Ideal for the purification of large viral antigens and recombinant protein vaccines at the laboratory scale.

• Nanoparticle Clarification: Provides a gentle, low-shear environment necessary for the washing and volume reduction of exosomes and lipid nanoparticles.

• Scalable Process Development: Part of the Spectrum filtration line, ensuring that performance data generated with this MidiKros module is directly applicable to larger MiniKros and KrosFlo production systems.

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