Repligen MiniKros Hollow Fiber Filter Sterile mPES 750 kDa

Repligen MiniKros S06-E750-05-S Hollow Fiber Filter – Sterile mPES, 750 kDa, 2600 cm2

The Repligen S06-E750-05-S is a high-capacity MiniKros Sampler hollow fiber module designed for pilot-scale Tangential Flow Filtration (TFF). Utilizing proprietary modified Polyethersulfone (mPES) membrane technology, this filter offers high flux rates and exceptional product recovery with minimal non-specific binding. This "S" designation indicates that the module is supplied Gamma Irradiated (Sterile), providing a ready-to-use, closed-system solution for aseptic bioprocessing. With a 750 kDa MWCO and an expansive 2600 cm2 surface area, it is optimized for the concentration and diafiltration of larger volumes of biological samples, including viral vectors, vaccines, and nanoparticles.

Technical Performance and Design

• Enhanced Pilot-Scale Capacity: The 65 cm effective length and 2600 cm2 surface area provide a significant increase in throughput, reducing processing time for volumes up to 50 liters compared to shorter modules.

• Advanced mPES Membrane: The modified Polyethersulfone chemistry provides a hydrophilic, low-fouling surface that maximizes water permeability and ensures high product recovery (>95% typical) for sensitive biomolecules.

• 750 kDa Selective Barrier: Specifically tuned for large-molecule Ultrafiltration, providing high retention of viral particles while effectively clearing smaller host cell proteins and buffer components.

• Gamma Irradiated (Sterile): Supplied sterile and ready for immediate integration into aseptic flow paths, eliminating the need for pre-use sanitization and reducing the risk of batch contamination.

Product Specifications

• Catalog Number: S06-E750-05-S

• Module Family: MiniKros Sampler

• MWCO: 750 kDa

• Surface Area: 2600 cm2

• Effective Length: 65 cm

• Fiber ID: 0.5 mm

• Connections: 3/4" Sanitary Flange (TC) Inlet, Retentate, and Permeate ports.

• Sterility: Gamma Irradiated (Sterile)

Key Benefits & Applications

• Viral Vector Concentration: Extensively used in gene therapy for the sterile concentration and buffer exchange of AAV and Lentiviral vectors at the pilot manufacturing scale.

• Vaccine Production: Ideal for the purification of large viral antigens and recombinant protein vaccines where high throughput is required.

• Exosome & Nanoparticle Processing: Provides a gentle, sterile environment for the clarification and washing of extracellular vesicles and lipid nanoparticles.

• Full Scalability: Part of the Spectrum filtration line, ensuring that performance data is directly applicable to larger KrosFlo production-scale systems.

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