Repligen Silicone Gasket 3/4 in. Total of 10 Gaskets

Repligen ACGS-75S-05N Sanitary Silicone Gasket – 3/4 in. Tri-Clamp

The Repligen ACGS-75S-05N is a precision-engineered sanitary gasket designed to provide a secure, leak-proof seal in critical bioprocessing and pharmaceutical fluid pathways. Calibrated to fit standard 3/4-inch Tri-Clamp connections, this gasket ensures a seamless, flush alignment between mating flanges. This flush fit is vital for preventing fluid stagnation, dead legs, and biofilm accumulation in sanitary lines. Manufactured from high-purity, medical-grade silicone, the ACGS-75S-05N offers excellent flexibility, chemical compatibility, and thermal resistance. It is an essential hardware component for assembling Tangential Flow Filtration (TFF) modules, bioreactor feed lines, and sterile transfer manifolds, ensuring the integrity of the fluid path from upstream processing to final fill-and-finish.

Technical Performance and Design

• Mini Tri-Clamp Compatibility: Specifically dimensioned for 3/4" TC fittings, providing a smooth internal bore that matches the tubing diameter to maintain optimal, low-shear fluid dynamics.

• High-Purity Silicone: Formulated to meet rigorous pharmaceutical standards, providing an ultra-low extractable and leachable profile that will not interact with or contaminate sensitive biological products.

• Thermal and Sterilization Resilience: The silicone elastomer withstands extreme temperatures, making it fully compatible with repeated Autoclave cycles (121°C), Steam-in-Place (SIP), and Clean-in-Place (CIP) protocols.

• Superior Compressibility: The inherent elasticity of the silicone ensures a tight, resilient seal that compensates for minor flange imperfections and withstands the pressure fluctuations common in pump-driven filtration.

Product Specifications

• Catalog Number: ACGS-75S-05N

• Fitting Size: 3/4 inch (Mini Tri-Clamp / Tri-Clover)

• Material: Sanitary Silicone Elastomer

• Format: Flanged Sanitary Gasket

• Sterilization: Autoclavable, SIP, and Gamma compatible

Key Benefits & Applications

• TFF and Chromatography: Frequently utilized to securely connect Repligen / Spectrum hollow fiber filters (like the MicroKros or MidiKros) to KrosFlo pump systems without risking pressure leaks.

• Aseptic Fluid Transfer: The industry standard for connecting stainless steel piping, valves, and single-use tubing assemblies in GMP manufacturing environments.

• Easy Visual Inspection: The translucent nature of the silicone makes it easy to spot physical wear, particulate accumulation, or improper seating during routine maintenance.

• Cost-Effective Consumable: Provides reliable performance and longevity, reducing the frequency of gasket replacements and minimizing the risk of costly batch contamination.

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