Sartorius Disposable Filter 0.2 um SartoScale 25 Sealed Pack of 6 Filters

Sartorius SartoScale 25 Disposable Filter Capsule – 0.2 µm, Sartopore 2 (5445307HV--LX--C)

The Sartorius 5445307HV--LX--C SartoScale 25 is a precision-engineered disposable filter capsule designed for small-scale filtration trials and scale-up studies. Featuring the high-performance Sartopore 2 heterogeneous PES membrane (0.45 µm pre-filter + 0.2 µm final filter), this capsule is the industry standard for determining the filterability of pharmaceutical and biological fluids. The SartoScale 25 provides an exact linear scale-down of full-sized Sartopore 2 cartridges, allowing researchers to accurately predict the throughput and performance of large-scale filtration systems while using minimal product volume. Supplied sterile and individually packaged, this capsule ensures the highest level of purity for sensitive biopharmaceutical applications.

Technical Performance and Design

• Heterogeneous Double Layer Membrane: Utilizes a 0.45 µm + 0.2 µm Polyethersulfone (PES) combination. The built-in pre-filter layer significantly increases total throughput and protects the final 0.2 µm sterilizing-grade layer from premature clogging.

• Linear Scale-Up Reliability: Specifically designed to mimic the fluid dynamics and membrane behavior of industrial Sartopore 2 filter cartridges, providing dependable data for process development and validation.

• Low Non-Specific Binding: The PES membrane is chemically modified for low protein and preservative binding, ensuring that active pharmaceutical ingredients (APIs) are not lost during the filtration process.

• Compact SartoScale 25 Format: Features an effective filtration area of 25 cm², making it the ideal size for benchtop trials with high-value biologicals or small-batch sterile filtration.

Product Specifications

• Catalog Number: 5445307HV--LX--C

• Pore Size: 0.2 µm (Sterilizing Grade)

• Effective Filtration Area (EFA): 25 cm²

• Membrane Material: Polyethersulfone (PES)

• Housing Material: Polypropylene

• Connections: 1/4" (6 mm) Hose Barb Inlet/Outlet

• Sterility: Sterile / Gamma Irradiated

Key Benefits & Applications

• Filterability Trials (Vmax): Used to determine the maximum volume of a specific liquid that can be filtered per unit area, a critical step in sizing industrial filtration systems.

• Sterile Filtration of Biologicals: Optimized for the filtration of cell culture media, serum, monoclonal antibodies, and vaccines where high throughput is required.

• Pharmaceutical R&D: Essential for the small-batch production of clinical trial materials, ensuring the filtration process is fully compliant with regulatory scale-up requirements.

• Broad Chemical Compatibility: The Polypropylene and PES construction provides stable performance across a pH range of 1 to 14, making it compatible with a variety of buffers and reagents.

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