Sartorius Filter Capsule Sartopore 2 XLI SartoScale 25 0.2 um 6 Filters

Sartorius 5445307IV--LX--C Sartopore 2 XLI SartoScale 25 Filter Capsule – 0.2 µm, PES

The Sartorius 5445307IV--LX--C is a highly specialized SartoScale 25 liquid filter capsule designed for small-scale sterile fluid processing and precise scale-up modeling. Part of the industry-leading Sartopore 2 XLI family, this filter features a double-layer Polyethersulfone (PES) membrane, utilizing a 0.35 µm built-in pre-filter followed by a 0.2 µm sterilizing-grade final membrane. The "XLI" (Extended Life) designation indicates that this membrane is specifically optimized for exceptionally high throughput and rapid flow rates when handling complex biological fluids. Equipped with standard Luer Lock connections for rapid integration into benchtop setups, this single-use capsule allows process engineers to conduct accurate filterability trials with minimal sample volumes before transitioning to costly production-scale cartridges.

Technical Performance and Design

• Double-Layer XLI Membrane: Features a heterogeneous PES construction (0.35 µm over 0.2 µm) that significantly increases total throughput and prevents premature fouling, especially with high-titer cell culture media or viscous protein solutions.

• SartoScale 25 Format: Engineered to precisely mirror the fluid dynamics and flow path of full-scale Sartopore 2 XLI production cartridges, ensuring highly reliable linear scale-up calculations from R&D to manufacturing.

• Ultra-Low Protein Binding: The hydrophilic PES membrane chemistry minimizes non-specific binding, ensuring maximum recovery of high-value active pharmaceutical ingredients (APIs) and monoclonal antibodies (mAbs) during small-batch filtration.

• Luer Lock Connectivity: Designed with standard Luer Lock inlet and outlet ports, making it ideal for syringe-driven trials or direct connection to small-diameter tubing in laboratory peristaltic pump systems.

Product Specifications

• Catalog Number: 5445307IV--LX--C

• Product Family: Sartopore 2 XLI (Extended Life) / SartoScale 25

• Pore Size: 0.2 µm Final (0.35 µm Pre-filter layer)

• Membrane Material: Polyethersulfone (PES)

• Capsule Material: Polypropylene

• Connections: Luer Lock (Inlet / Outlet)

• Filter Type: Sterilizing Grade Liquid Filter

Key Benefits & Applications

• Process Development & Scale-Up: The industry gold standard for conducting initial filter sizing trials, performing capacity testing, and defining sterile filtration protocols without wasting large volumes of expensive feed material.

• Biopharmaceutical Sterile Filtration: Validated for the complete retention of Brevundimonas diminuta, ensuring biological safety for buffers, media, and intermediate APIs.

• High-Fouling Fluids: The asymmetric pre-filtration layer makes this capsule an excellent choice for clarifying and sterilizing complex media blends, lipid-containing solutions, and high-concentration protein formulations.

• Single-Use Efficiency: Eliminates the need for complex cleaning-in-place (CIP) and sterilization-in-place (SIP) validations, offering a simple plug-and-play solution for busy R&D laboratories.

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