Sartorius SartoScale Filter Sartopore 2 0.2 um Pack of 3 Filters

Sartorius 5445307HS--FF--M SartoScale Sartopore® 2 0.2 µm Filter

The Sartorius 5445307HS--FF--M is a specialized SartoScale filtration unit designed for reliable scale-down studies and filterability testing in biopharmaceutical process development. Featuring the industry-leading Sartopore® 2 heterogeneous double-layer PES membrane, this unit utilizes a 0.45 µm pre-filter layer and a 0.2 µm final sterilizing-grade membrane. This dual-layer architecture is engineered to provide exceptional total throughput and high flow rates by protecting the final membrane from premature fouling. The SartoScale format ensures that the membrane material, pleated geometry, and support fleece are identical to full-scale Sartopore® 2 cartridges, allowing for linear scale-up and predictable performance during the transition from pilot to commercial manufacturing.

Technical Performance and Design

• Heterogeneous Double-Layer PES: The integrated 0.45 µm pre-filter effectively captures larger particulates and aggregates, significantly extending the life of the 0.2 µm sterilizing-grade layer for complex biological fluids.

• Validated Scale-Down Performance: Specifically calibrated to mimic the flux and capacity of large-scale cartridges, enabling researchers to determine the required filtration area for a full-scale process using minimal product volumes.

• Optimized Hydrophilic Membrane: The PES chemistry is naturally hydrophilic and exhibits ultra-low non-specific binding, ensuring maximum recovery of valuable proteins, monoclonal antibodies, and active ingredients.

• Broad Chemical Compatibility: The robust polypropylene housing and PES membrane provide excellent stability across a pH range of 1 to 14, making it compatible with a wide variety of buffers and process chemicals.

Product Specifications

• Catalog Number: 5445307HS--FF--M

• Media Type: Sartopore® 2 (Polyethersulfone / PES)

• Pore Size: 0.45 µm + 0.2 µm (Sterilizing Grade)

• Format: SartoScale (Size M)

• Effective Filtration Area (EFA): 4.5 cm²

• Connectors: Female Luer Lock (Inlet) / Female Luer Lock (Outlet)

• Sterility: Non-sterile (Autoclavable at 121°C or 134°C)

• Regulatory Compliance: Meets USP Class VI Plastic tests; Certified non-pyrogenic.

Key Benefits & Applications

• Filterability Trials (Vmax): The essential tool for performing Vmax studies to calculate the minimum filter area required for production batches, reducing capital expenditure and waste.

• Cell Culture Media & Buffers: Ideal for small-volume sterilization and clarification of nutrient-rich media and protein-containing solutions during R&D stages.

• Process Optimization: Allows for the rapid screening of different membrane chemistries or pore sizes under identical process conditions to ensure optimal product quality.

• Biologics Manufacturing: Designed for the high-purity requirements of vaccine, mAb, and recombinant protein production, ensuring a sterile and particulate-free filtrate.

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