SmartFlow Technologies ConSep 7000 Filter Module PES 10 kD

SmartFlow Technologies 81-M2B-0010 ConSep 7000 Filter Module – 10 kDa, PES, 0.65 mm

The SmartFlow Technologies 81-M2B-0010 is a premium ConSep 7000 tangential flow filtration (TFF) module engineered for high-efficiency downstream bioprocessing. Utilizing SmartFlow's proprietary flow channel technology, this module is designed to maximize mass transfer while minimizing concentration polarization and membrane fouling. Equipped with a highly hydrophilic 10 kDa Polyethersulfone (PES) membrane, it is precisely tuned for the ultrafiltration, concentration, and diafiltration of vital biomolecules. The 0.65 mm channel height is specifically optimized to provide a gentle yet highly effective sweep across the membrane surface, maintaining high flux rates even as the retentate viscosity increases during final-stage concentration.

Technical Performance and Design

• Advanced ConSep Fluid Dynamics: The unique internal geometry of the ConSep platform creates an optimized fluid path that enhances shear at the membrane surface, continuously sweeping away deposited solids and drastically reducing the fouling that plagues traditional flat-sheet cassettes.

• 10 kDa Ultrafiltration Membrane: The precise 10,000 Dalton MWCO ensures the complete retention of monoclonal antibodies (mAbs), recombinant proteins, and larger peptides while allowing salts, buffers, and low-molecular-weight impurities to pass freely into the permeate.

• 0.65 mm Channel Height: Provides the ideal crossflow dynamics for processing fluids with moderate viscosities and cell debris, balancing the need for high shear against the risk of creating excessive pressure drops in the system.

• Ultra-Low Protein Binding: The PES membrane chemistry prevents non-specific binding of expensive biologicals to the filter surface, ensuring maximum volumetric recovery and high final product yields.

Product Specifications

• Catalog Number: 81-M2B-0010

• Product Line: ConSep 7000

• Membrane Material: Polyethersulfone (PES)

• Molecular Weight Cut-Off (MWCO): 10 kDa

• Channel Height: 0.65 mm

• Filtration Type: Tangential Flow Filtration (TFF) / Ultrafiltration

Key Benefits & Applications

• Protein Concentration & Diafiltration: The gold standard configuration for desalting and concentrating target proteins and enzymes prior to final formulation or chromatography steps.

• High Flux Maintenance: The ConSep design sustains consistently high permeate flux rates over extended processing times, significantly reducing overall batch processing hours in the pilot plant or manufacturing suite.

• Scalable Architecture: The fluid dynamics of the 7000 series accurately mirror those of larger SmartFlow modules, providing process engineers with reliable data for linear scale-up to commercial production.

• Viscous Fluid Handling: The 0.65 mm channel provides enough clearance to safely process high-concentration protein solutions without the immediate risk of plugging the retentate channels.

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