SmartFlow Technologies ConSep 7000 Filter Module PES 5 kD MWCO

SmartFlow Technologies 81-M2B-0005 ConSep 7000 Filter Module

The SmartFlow Technologies 81-M2B-0005 is a precision-engineered ConSep 7000 filter module designed for high-efficiency Tangential Flow Filtration (TFF). Utilizing SmartFlow's proprietary patented plate-and-frame geometry, this module features an open-channel design that provides uniform fluid dynamics across the entire membrane surface. This specialized architecture is specifically optimized to eliminate "dead zones" and minimize gel-layer formation, allowing for superior flux rates and higher concentration factors than traditional filter formats. The 81-M2B-0005 is ideal for processing challenging feedstreams, including high-viscosity lysates, whole-cell slurries, and delicate proteins. Manufactured with high-purity, chemically resistant materials, this module is engineered for scalability from process development to full-scale production, ensuring consistent performance and predictable linear scale-up for critical biopharmaceutical separation and purification workflows.

Technical Performance and Design

• Patented Open-Channel Geometry: Provides a uniform path for the feedstream, significantly reducing the risk of clogging and allowing for the successful processing of high-solids concentrations.

• Enhanced Shear Management: The fluid dynamics within the ConSep 7000 are designed to be gentle on sensitive biological structures, preserving the integrity of cells, viral vectors, and complex proteins during concentration and diafiltration.

• Efficient Diafiltration: Optimized flow distribution allows for rapid buffer exchange with minimal volume requirements, reducing process time and reagent consumption.

• Scalable Architecture: The ConSep 7000 series is designed to be stacked or paralleled, providing a direct linear scale-up from the 81-M2B-0005 module to larger industrial systems.

Product Specifications

• Catalog Number: 81-M2B-0005

• Series: ConSep 7000

• Filter Geometry: Plate-and-Frame / Flat Sheet

• Configuration: Tangential Flow Filtration (TFF)

• Materials: USP Class VI compliant polymers and high-performance membranes

• Application: Concentration, Clarification, and Diafiltration

Key Benefits & Applications

• Biopharmaceutical Purification: Extensively used in the harvesting of recombinant proteins and monoclonal antibodies (mAbs) from dense fermentation broths.

• Cell Processing: Ideal for the concentration of mammalian, bacterial, or yeast cells where maintaining high viability is essential for downstream steps.

• Vaccine Production: Provides the high resolution required for the clarification and concentration of viral particles and sub-unit vaccines.

• Reduced Fouling: The uniform flow characteristics ensure that the membrane surface is effectively "swept," extending the life of the module and maintaining high permeate flux over extended run times.

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