Thermo Scientific Biotainer Bottle Closure 3 Ports 48 mm Case of 4 Caps

Thermo Scientific Nalgene 2560-0489 Biotainer Closure – 3 Ports, 48 mm, Sterile

The Thermo Scientific Nalgene 2560-0489 is a specialized 3-ported closure designed for aseptic fluid transfer in biopharmaceutical and biotechnology applications. Engineered specifically for Biotainer™ bottles and carboys with a 48 mm Quick Action (QA) neck, this closure enables efficient filling, venting, and liquid withdrawal within a closed system. Manufactured from radiation-stabilized polypropylene with a securely bonded silicone liner, the 2560-0489 ensures a leak-proof seal even during low-temperature storage. The ported design eliminates the need for manual capping and uncapping during fluid transfer, significantly reducing the risk of environmental contamination and protecting high-value biological contents.

Technical Performance and Design

• Tri-Port Configuration: Features two 8 mm fluid ports designed to accept 6–7 mm (1/4 in.) I.D. tubing and one dedicated vent port designed for 4.5 mm (3/16 in.) tubing.

• Integrated Silicone Liner: The closure includes an ultrasonically welded silicone liner that provides a reliable, airtight seal and prevents the liner from falling out or becoming a contamination risk.

• Quick Action (QA) Threading: Specifically designed for the 48 mm QA neck finish found on 1L to 20L Biotainers, providing a secure, strip-proof fit with minimal application torque.

• Biocompatible Materials: Constructed from USP Class VI resins that are non-cytotoxic, non-pyrogenic, and Animal Derived Component-Free (ADCF) to ensure the integrity of pH-sensitive media and active ingredients.

Product Specifications

• Catalog Number: 2560-0489

• Closure Size: 48 mm QA (Quick Action)

• Number of Ports: 3 (Two Fluid Ports, One Vent Port)

• Material: Radiation-stabilized Polypropylene (PP)

• Liner Material: Platinum-cured Silicone

• Compatibility: Fits 1L to 20L PC and PETG Biotainer Bottles and Carboys

• Sterility: Gamma Irradiated / Sterile

Key Benefits & Applications

• Aseptic Fluid Transfer: Facilitates the sterile transfer of culture media, buffers, and active pharmaceutical ingredients (APIs) between vessels in a closed-loop system.

• Ready-to-Use (RTU): Supplied sterile and double-bagged in a cleanroom-compatible format, allowing for immediate integration into aseptic manufacturing workflows.

• Low-Temperature Resilience: Suitable for use in storage conditions down to -40°C, making it ideal for the frozen transport of bulk intermediates.

• Validation Support: Manufactured in an ISO 14644-1 Class 7 cleanroom, providing the high level of documentation and purity required for regulated bioprocessing.

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