Thermo Scientific Bottletop Filter 1000 ml Rapid Flow 0.45 um PES Case of 12

Thermo Scientific Nalgene 167-0045 1000 ml Rapid-Flow™ Bottle-Top Filter (0.45 µm PES)

The Thermo Scientific Nalgene 167-0045 is a 1-liter sterile bottle-top filtration unit designed for the rapid clarification of large-volume laboratory reagents, buffers, and aqueous solutions. Featuring the proprietary Rapid-Flow™ support column design, this unit maximizes filtration speed and throughput while maintaining high structural integrity under vacuum. The 0.45 µm Polyethersulfone (PES) membrane provides superior flow rates and exceptionally low protein binding, ensuring that critical solutes are not lost during the filtration process. This filter is designed to screw directly onto standard glass or plastic media bottles with a 45 mm (GL45) neck finish, providing a secure, leak-proof aseptic transfer path.

Technical Performance and Design

• Rapid-Flow™ Support Plate: The unique internal geometry provides a uniform support surface for the membrane, reducing turbulence and allowing for faster filtration times compared to traditional support designs.

• High-Flux PES Membrane: The 0.45 µm Polyethersulfone membrane is naturally hydrophilic and contains no wetting agents, offering a high flow rate for aqueous solutions and superior chemical resistance.

• Low Protein Binding: Specifically engineered for the filtration of protein-rich solutions, such as serum-supplemented media and monoclonal antibody buffers, ensuring minimal loss of high-value biological analytes.

• Secure GL45 Interface: The 45 mm thread size ensures universal compatibility with standard laboratory media bottles, including Nalgene, Schott, and Corning brands, creating a closed-system environment during filtration.

Product Specifications

• Catalog Number: 167-0045

• Volume Capacity: 1000 ml

• Membrane Type: Polyethersulfone (PES)

• Pore Size: 0.45 µm (Clarification Grade)

• Neck Size: 45 mm (GL45)

• Membrane Diameter: 90 mm

• Sterility: Sterile (Gamma Irradiated); Non-pyrogenic; Non-cytotoxic

• Packaging: 12 Units per Case

Key Benefits & Applications

• Buffer & Reagent Clarification: Optimized for the removal of particulates and large colloidal matter from laboratory buffers, salt solutions, and mobile phases.

• Cell Culture Support: Ideal for clarifying aqueous solutions that will be subsequent sterile-filtered (0.22 µm), extending the life of the final sterilizing membrane.

• High Throughput Workflows: The large 90 mm membrane diameter and Rapid-Flow technology make this the preferred choice for processing 1-liter batches quickly without membrane clogging.

• Certified Biological Safety: Each lot is tested for sterility and is certified non-cytotoxic, ensuring it will not interfere with sensitive cell-based assays or pharmaceutical development.

All product names, logos, and brands are property of their respective owners. Nalgene and Rapid-Flow are trademarks of Thermo Fisher Scientific.