Thermo Scientific Carboy Aseptic Closure with 1/4 in. and Two 1/8 in. ID Ports

Thermo Scientific Nalgene Aseptic Closure (83B Closure, Catalog 2135-3803)

The Thermo Scientific Nalgene 2135-3803 is a specialized cap assembly engineered to transform standard Nalgene carboys into high-integrity, closed fluid transfer systems. Designed specifically for vessels with an 83B (83 mm) neck finish—typically ranging from 10L to 50L capacities—this closure facilitates the aseptic filling, venting, and dispensing of critical fluids without environmental exposure. The assembly features a precision-engineered three-port configuration that eliminates the contamination risks and leakage common with manually drilled caps. By allowing the entire carboy and tubing manifold to be sterilized as a single unit, the 2135-3803 significantly streamlines both upstream and downstream bioprocessing workflows.

Technical Performance and Design

• Secure 83B Interface: Designed for large-format carboys, the high-torque polypropylene (PP) screw cap provides a robust mechanical seal capable of withstanding the rigors of pharmaceutical transport and storage.

• Platinum-Cured Silicone Gasket: Includes a high-purity silicone gasket that ensures a leak-proof seal even during the thermal expansion and contraction cycles of autoclaving, preventing bypass contamination.

• Integrated Tri-Port Layout: Features a versatile port configuration including one 1/4-inch ID port for primary liquid transfer and two 1/8-inch ID ports optimized for venting, sampling, or reagent additions.

• Contamination-Free Construction: Precision-molded ports eliminate the burrs and irregularities associated with manual drilling, ensuring a perfectly circular path for tubing or connectors to maintain a sterile barrier.

Product Specifications

• Catalog Number: 2135-3803

• Closure Size: 83B (83 mm)

• Primary Port: 1/4-inch (6.4 mm) ID

• Secondary Ports: Two 1/8-inch (3.2 mm) ID

• Materials: Polypropylene (Cap), Platinum-Cured Silicone (Gasket)

• Sterility/Sanitation: Non-sterile; Fully Autoclavable (121°C)

• Regulatory: Manufactured from USP Class VI compliant materials; Non-cytotoxic.

Key Benefits & Applications

• Bulk Liquid Transfer: The 1/4" port is ideal for connecting dip tubes to enable the complete, aseptic extraction of media or buffers from 20L or 50L carboys.

• Sterile Venting & Pressure Equalization: Dedicated 1/8" ports allow for the permanent attachment of 50mm PTFE vent filters, ensuring safe pressure equilibration during autoclaving and fluid dispense.

• Large-Scale Bioprocessing: Specifically designed for large-volume Nalgene carboys used in vaccine manufacturing, cell culture scale-up, and bulk reagent storage.

• Modular Versatility: The three-port design supports complex manifold setups, allowing researchers to create customized, validated fluid paths for diafiltration or harvest collection.

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