Thermo Scientific Rapid-Flow Filter Unit 0.45 PES 500 ml 10 Filter Units

Thermo Scientific Nalgene 166-0045 Rapid-Flow Filter Unit – 500 mL, 0.45 µm PES

The Thermo Scientific Nalgene 166-0045 is a complete, single-use vacuum filtration unit designed for the rapid clarification, buffer preparation, and particle removal of biological fluids. The system features a 500 mL upper filter funnel and a matching 500 mL receiver storage bottle, both molded from optically clear polystyrene. It is equipped with a high-performance, asymmetric Polyethersulfone (PES) membrane featuring a 0.45 µm pore size. Utilizing the proprietary Rapid-Flow multi-column support matrix, the unit optimizes fluid dynamics to deliver exceptionally fast flow rates and high throughput while maintaining an airtight, leak-proof seal during vacuum applications.

Technical Performance and Design

• Asymmetric PES Membrane: The 0.45 µm polyethersulfone membrane provides low non-specific protein binding and low extractables, ensuring the chemical composition of sensitive biological solutions remains unaltered.

• Rapid-Flow Support Grid: The engineered multi-column support matrix beneath the membrane prevents target deformation and maximizes active surface area, significantly reducing filtration times compared to traditional concentric ring designs.

• Leak-Proof Closure System: The receiver bottle is supplied with a heavy-duty, blue high-density polyethylene (HDPE) screw cap featuring no liner to eliminate a common source of trace contamination or chemical leaching.

• Stable Base Profile: The wide, stable footprint of the receiver bottle resists tipping on the benchtop during vacuum hose attachment, enhancing laboratory safety.

Product Specifications

• Catalog Number: 166-0045 (also written as 1660045)

• Product Line: Nalgene Rapid-Flow

• Capacity: 500 mL Upper Funnel / 500 mL Receiver Bottle

• Membrane Material: Polyethersulfone (PES)

• Pore Size: 0.45 µm

• Housing Material: Polystyrene (PS)

• Sterility: Sterile, Non-Pyrogenic, and Cytotoxic-Safe

• Neck Diameter: 50 mm

Key Benefits & Applications

• Buffer Clarification: The industry-standard choice for filtering large volumes of laboratory buffers, reagents, and aqueous microbiological media ingredients.

• Particle Removal: The 0.45 µm pore classification effectively captures fine precipitates, cellular fragments, and dense particulates that could otherwise clog sensitive analytical instrumentation.

• Workflow Efficiency: Eliminates the tedious setup, manual cleaning, and sterilization required for reusable glass filtration hardware, allowing for immediate "plug-and-play" operation via standard vacuum lines.

• Safe Sample Storage: The clear polystyrene receiver storage bottle serves as a robust container for short-to-medium-term cold storage of processed liquids.

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