{"product_id":"thermo-scientific-top-works-for-nalgene-carboy-3-port-aseptic-closure","title":"Thermo Scientific Top Works for Nalgene Carboy - 3 Aseptic Closure Systems","description":"\u003ch3\u003eThermo Scientific Nalgene Top Works™ Flexible System (53B Closure, Catalog 2135-5303)\u003c\/h3\u003e\n\u003cp\u003eThe Thermo Scientific Nalgene Top Works™ 2135-5303 is a premium, \"plug-and-play\" closure assembly designed to create an instant aseptic fluid transfer system. Unlike standard ported caps that require manual tubing insertion, this system features platinum-cured silicone tubing fused directly into a thermoplastic elastomer (TPE) stopper insert. This \"one-piece\" integrated construction eliminates the risk of tubing slippage or bypass leakage at the insertion point, providing a significantly higher level of sterility assurance for critical upstream applications. Engineered to fit vessels with a 53B (53 mm) neck finish, this assembly is the standard choice for smaller Nalgene carboys and heavy-duty vacuum bottles.\u003c\/p\u003e\n\n\u003ch3\u003eTechnical Performance and Design\u003c\/h3\u003e\n\u003cul\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003eFused One-Piece Construction:\u003c\/b\u003e The silicone tubing is permanently bonded to the TPE stopper, creating a seamless, leakproof interface that maintains its integrity even under the thermal stress of repeated autoclaving.\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003eVersatile 3-Port Configuration:\u003c\/b\u003e Features a specialized tri-port layout designed for simultaneous fluid management: two high-flow 1\/4-inch (6.4 mm) ID lines for inlet\/outlet streams and one 1\/8-inch (3.2 mm) ID line for venting or sampling.\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003ePlatinum-Cured Silicone Tubing:\u003c\/b\u003e Utilizes high-purity, ultra-flexible silicone that ensures low extractables and minimal binding of proteins or active pharmaceutical ingredients (APIs).\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003eLeakproof 53B Interface:\u003c\/b\u003e Designed with a precision-molded polypropylene screw cap that provides a secure, airtight seal on standard 53 mm neck finishes, making it ideal for vacuum or pressure-driven transfers.\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eProduct Specifications\u003c\/h3\u003e\n\u003cul\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003eCatalog Number:\u003c\/b\u003e 2135-5303\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003eClosure Size:\u003c\/b\u003e 53B (53 mm)\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003ePort 1 \u0026amp; 2:\u003c\/b\u003e 1\/4-inch (6.4 mm) ID Tubing\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003ePort 3:\u003c\/b\u003e 1\/8-inch (3.2 mm) ID Tubing\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003eMaterials:\u003c\/b\u003e Polypropylene (Cap), TPE (Stopper), Platinum-Cured Silicone (Tubing)\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003eSterility\/Sanitation:\u003c\/b\u003e Non-sterile; Fully Autoclavable (121°C, 15 psi for 20 min)\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003eRegulatory:\u003c\/b\u003e USP Class VI compliant; Non-cytotoxic; Food-grade (CFR 21.177)\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eKey Benefits \u0026amp; Applications\u003c\/h3\u003e\n\u003cul\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003eAseptic Inoculation:\u003c\/b\u003e Facilitates the sterile transfer of seed cultures into larger bioreactors while maintaining a closed system to prevent environmental contamination.\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003eMedia \u0026amp; Buffer Transfer:\u003c\/b\u003e The two 1\/4\" lines allow for efficient, high-volume fluid movement, while the 1\/8\" line is ideal for attaching a 0.2 µm vent filter to maintain pressure equilibrium.\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003eClosed-System Sampling:\u003c\/b\u003e Allows for the removal of small-volume samples through the dedicated 1\/8\" line without disrupting the main process flow or exposing the vessel contents.\u003c\/p\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cp style=\"margin: 0;\"\u003e\u003cb\u003ePlug-and-Play Integration:\u003c\/b\u003e Eliminates the labor-intensive process of fabricating custom carboy caps, providing a validated, off-the-shelf solution that reduces the risk of operator error.\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003chr\u003e\n\u003cp style=\"margin: 0; font-size: 0.8em;\"\u003e\u003ci\u003eAll product names, logos, and brands are property of their respective owners. Nalgene and Top Works are trademarks of Thermo Fisher Scientific.\u003c\/i\u003e\u003c\/p\u003e","brand":"Thermo Scientific","offers":[{"title":"Default Title","offer_id":44497100374268,"sku":"4021","price":104.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0627\/8463\/5132\/files\/thermo-scientific-top-works-for-nalgene-carboy-3-aseptic-closure-systems-bottles-thermo-scientific-746702.jpg?v=1778280817","url":"https:\/\/lifesciencestrading.com\/products\/thermo-scientific-top-works-for-nalgene-carboy-3-port-aseptic-closure","provider":"Life Sciences Trading","version":"1.0","type":"link"}