Waters Atlantis Guard Cartridge T3 Prep 5 um 30 x 10 mm

Waters Atlantis T3 Preparative Guard Cartridge – 30 x 10 mm, 5 µm Particle Size, 100Å Pore Size, Universal Reversed-Phase C18 Silica Chemistry, 1/pk (MPN: 186006879)

The Waters Corporation 186006879 (also cataloged as WT186006879) is a premium, chromatography-grade preparative guard cartridge precision-engineered to safeguard high-value preparative HPLC and SFC columns from chemical contaminants and particulate fouling. Packed with high-purity, universal silica-based Atlantis T3 reversed-phase C18 sorbent (5 µm spherical particles, 100Å pore structure), this 30 mm inner diameter (ID) by 10 mm length cartridge delivers balanced retention for both highly polar and non-polar hydrophobic molecules. Utilizing Waters' advanced T3 bonding and intermediate silanol endcapping technology, the cartridge provides superior peak shape, elite stability across a pH range of 2 to 8, and maximum resistance to aqueous mobile phase dewetting. Designed to be housed within a matching 30 x 10 mm prep guard holder, this cartridge effectively acts as a physical pre-filter, trapping strongly retained matrix impurities before they reach the main analytical bed to drastically extend overall column longevity.

Technical Performance and Design

• Advanced T3 C18 Bonding Technology: Utilizes a proprietary intermediate-density C18 ligand distribution bonded to ultra-pure spherical silica. This specific chemistry provides superior retention and separation of highly polar compounds while maintaining balanced interaction parameters for hydrophobic fractions.

• Elite Aqueous Mobile Phase Stability: Designed to resist polymer packing collapse or phase dewetting (phase collapse) when operating under 100% aqueous mobile phase conditions. This allows chromatographers to run aggressive polar gradients without losing retention performance.

• High-Pressure Preparative Architecture: Engineered to handle demanding preparative purification workflows, maintaining full physical packing and sealing integrity under high-flow system velocities up to an operational ceiling of 6,000 psi (415 bar).

• Minimized Excess Volumetric Band Spreading: Internal fluidic dynamics are tightly matched to standard 30 mm ID preparative column inlets. This fluidic transition minimizes dead volume and parasitic extra-column band broadening, preserving the high theoretical plate count of the downstream column.

Product Specifications

• Part Number / MPN: 186006879 (Cross-listed as WT186006879)

• Manufacturer / Brand: Waters Corporation

• Sorbent Suffix / Phase Chemistry: Atlantis T3 (Advanced Reversed-Phase C18)

• Dimensions: 30 mm Inner Diameter (ID) x 10 mm Length

• Particle Sizing Matrix: 5 µm (Spherical high-purity silica substrate)

• Pore Size Rating: 100Å

• System Fitment Requirement: Designed for direct installation inside the Waters 30 x 10 mm Prep Guard Holder (Part Number: 186006912) protecting 30 mm ID Prep OBD columns

• Operating Threshold Limits: pH Range: 2.0 to 8.0 / Temperature Ceiling: 45 C / Pressure Limit: 6,000 psi (415 bar)

• Carbon Loading Metric: 14% nominal carbon load profile

• Packaging Configuration: Single unit per pack (1/pk)

Key Benefits and Applications

• Preparative Column Cost Preservation: Acts as an sacrificial inline filter that intercepts heavily binding compounds, particulate precipitate, and pump seal wear debris, preventing early column replacement overhead.

• Pharmaceutical Small Molecule Isolation: The benchmark selection for pilot-scale purification setups, compound library isolation, and natural product extractions containing tough mixtures of polar and non-polar components.

• LC/MS Preparative Method Scale-Up: Strict cGMP and ISO 9001 factory batch testing ensures high lot-to-lot chemical reproducibility, facilitating trouble-free method scale-up from analytical tracking to massive prep purification runs.

• Robust Peak Tail Mitigation: Medium silanol activity coupled with intentional endcapping controls basic analyte interactions, delivering symmetric peak profiles and high resolution during mass purification loading surges.

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