WaterSep Hollow Fiber Filter Cartridge Researcher12 Green

WaterSep SU 750 10RES12 SO Researcher12 Green Hollow Fiber Filter – 750 kD, 444 cm²

The WaterSep BioSeparations SU 750 10RES12 SO is a premium ultrafiltration hollow fiber cartridge designed specifically for intermediate-scale bioprocessing and tangential flow filtration (TFF). As part of the single-use "Green Line," this Researcher12 module is provided gamma-irradiated, entirely glycerin-free, and ready for immediate deployment without the need for extensive pre-flushing. Featuring a highly hydrophilic modified Polyethersulfone (m-PES) membrane with a 750 kD molecular weight cut-off (MWCO) and a 1.0 mm fiber inner diameter, it is expertly tailored for the concentration and diafiltration of massive macromolecular assemblies. Equipped with robust sanitary flange connections, the Researcher12 provides predictable linear scale-up capabilities for processing batch volumes ranging from 400 mL to 6 Liters.

Technical Performance and Design

• Green Line Ready-to-Use Technology: Manufactured without humectants or storage glycerin, this cartridge generates virtually zero extractables. It can be plumbed directly into the process line and utilized immediately, drastically reducing setup times and buffer consumption.

• 750 kD Ultrafiltration Membrane: The large 750 kD MWCO is precisely controlled to retain massive structures like viral particles and extracellular vesicles while allowing smaller host cell proteins, DNA fragments, and buffers to pass freely into the permeate.

• Wide 1.0 mm Fiber Lumen: The open-channel, 1.0 mm inner diameter provides a gentle, low-shear fluid path that is essential for preserving the structural integrity and biological activity of fragile viral vectors and lipid nanoparticles during high-speed recirculation.

• Sanitary Flange Connections: The "SO" configuration indicates standard Tri-Clamp/Sanitary connections on the feed and retentate ports, providing a highly secure, leak-proof interface with pilot-scale bioprocessing skids and automated TFF systems.

Product Specifications

• Catalog Number: SU 750 10RES12 SO

• Product Line: Researcher12 (Green Line)

• Molecular Weight Cut-Off (MWCO): 750 kD

• Membrane Material: Modified Polyethersulfone (m-PES)

• Fiber Inner Diameter (ID): 1.0 mm

• Effective Filtration Area: 444 cm²

• Connections: Sanitary Flange / Tri-Clamp (SO)

• Sterility: Single-Use, Pre-sterilized (Gamma Irradiated)

Key Benefits & Applications

• Gene Therapy & Virology: The 750 kD size provides an exceptional balance of flux and retention for the purification and concentration of Lentiviral vectors, Adenoviruses, and adeno-associated viruses (AAV).

• Exosome Isolation: An efficient, scalable alternative to ultracentrifugation for the high-yield harvesting and washing of extracellular vesicles from clarified cell culture supernatants.

• Bridging R&D and Production: The Researcher12 format is perfectly scaled for process optimization, pilot studies, and the production of early-phase clinical materials before transitioning to massive multi-square-meter modules.

• Secure Fluid Dynamics: Upgrading to sanitary flanges ensures that the filtration loop can safely handle the elevated backpressures required for continuous diafiltration without the risk of tubing blowouts.

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