Waters Oasis MCX Microelution Microplate 30 um 96 Well Plate

Waters Oasis MCX Microelution SPE Plate – 30 µm, 96-Well

The Waters 186001830BA is a high-performance Solid Phase Extraction (SPE) microplate engineered for the rapid, high-throughput isolation of basic compounds from ultra-low volume biological samples. Configured in Waters' specialized microelution format, each well in the 96-well manifold contains a minimal 2 mg bed of Oasis MCX, a 30 µm mixed-mode polymeric sorbent. Built upon a rugged, water-wettable copolymer backbone, this sorbent resists deconditioning if accidentally dried out during the conditioning or washing steps, entirely eliminating the risk of lost sample recoveries. By utilizing a strong cation-exchange sulfonic acid group alongside reversed-phase retention, it allows for highly aggressive organic wash steps. The microelution design enables analyte elution in volumes as low as 25 µL, completely bypassing the nitrogen dry-down step that frequently causes adsorptive losses of "sticky" analytes to the walls of collection plates. This results in ultra-clean, highly concentrated extracts that are immediately ready for LC-MS/MS analysis.

Technical Performance and Design

• Mixed-Mode Chemistry: Synergistically combines strong cation-exchange capabilities with reversed-phase retention, providing unparalleled selectivity and recovery for basic analytes and pharmaceutical compounds.

• Microelution Efficiency (2 mg): The ultra-low sorbent mass is explicitly optimized for micro-volume biological samples. It allows for highly concentrated elution volumes (25–50 µL), drastically reducing processing time by completely eliminating the need for solvent evaporation and reconstitution.

• Water-Wettable Polymer: The advanced Oasis backbone ensures that the sorbent bed will not collapse or lose retention capacity if it runs dry under a vacuum manifold, guaranteeing robust, highly reproducible extraction recoveries.

• Direct-to-Vial Workflow: The concentrated extracts can be eluted directly into an analytical collection plate or autosampler vial insert, streamlining the transition from sample preparation directly to the mass spectrometer.

Product Specifications

• Catalog Number: 186001830BA

• Format: 96-Well Microelution Plate

• Phase/Chemistry: Oasis MCX (Mixed-Mode Strong Cation Exchange)

• Particle Size: 30 µm

• Sorbent Mass: 2 mg per well

• Target Analytes: Basic Compounds and Amines

Key Benefits & Applications

• Eliminates Evaporation Losses: Bypassing the dry-down step is critical for volatile compounds or basic peptides that frequently stick irreversibly to the plastic walls of collection plates during solvent evaporation.

• Low-Volume Sample Extraction: The absolute gold standard for pediatric testing, dried blood spots, or any clinical diagnostic assay where the available biological sample volume is strictly limited.

• LC-MS/MS Optimization: Highly effective at stripping away phospholipids, salts, and particulates, preventing the severe ion-suppression effects that frequently plague sensitive mass spectrometry detectors.

• High-Throughput Automation: The standard SBS footprint is perfectly optimized for automated liquid handling robots, positive pressure manifolds, and rapid batch processing without manual intervention.

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